Women with a higher intake of dietary saturated fats have fewer mature oocytes available for collection in IVF, according to results of a study from the Harvard School of Public Health funded by the US National Institutes of Health. The study investigated the effect of dietary fat (classified as total, saturated, monounsaturated, polyunsaturated, omega 6, omega 3 and trans) on a range of preclinical and clinical outcomes in women having IVF.
The chance of IVF success reduced by around 50 percent by coffee consumption of 5 or more cups a day
Women who drink five or more cups of coffee a day severely reduce their chance of success from IVF treatment. Indeed, Danish investigators who followed up almost 4000 IVF and ICSI patients described the adverse impact as "comparable to the detrimental effect of smoking".
A woman's race may determine whether vitamin D helps them to conceive through IVF.
The sunshine vitamin is famed for its benefit to bones and the immune system, but it also plays a role in conception. Now, evidence suggests that the vitamin's benefits may only apply to certain racial groups – while white women can boost their IVF success rates with vitamin D, the opposite appears to be true for Asian women.
A new study led by scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) found that a healthy intake of micronutrients is strongly associated with improved sperm DNA quality in older men. In younger men, however, a higher intake of micronutrients didn't improve their sperm DNA.
According to Dr. Racowsky, in order for an egg to have the best chance of fertilizing and supporting embryo development, it should be "mature" with one spindle (a critical egg structure) on which is attached one organized set of chromosomes. This study found severely obese women have a much greater chance of having eggs with multiple spindles and disorganized chromosomes.
The study also has a second major finding. It is the first study to show that the chances of having a baby after IVF is closely related to the amount of DNA damage a man has in each of his sperm. A little damage is normal (under 15 per cent per sperm), as is seen in the sperm of fertile men. But if the damage reaches clinically important levels (high sperm DNA damage more than 25 per cent per sperm) it will reduce the couples' chances of a family, even with some forms of fertility treatment.
Using a new IVF technique could considerably increase older women's chances of pregnancy, a small clinical trial presented at a fertility conference suggests.
In the technique embryos produced via IVF are first tested for major genetic abnormalities using a method called comprehensive chromosomal screening (CCS). For this, samples are taken from embryos at the blastocyst stage, when they have around 100 cells.
“Oocyte cryopreservation is an exciting and improving technology, and should no longer be considered experimental. Pregnancy rates and health outcomes of the resulting children are now comparable to those of IVF with fresh eggs,” said Eric Widra, MD, Chair of the Society for Assisted Reproductive Technology (SART) Practice Committee.