George M Grunert MD, Reproductive Endocrinologist, HFS IVF Program Director

High sperm DNA damage a leading cause of 'unexplained infertility', research finds

High sperm DNA damage a leading cause of 'unexplained infertility', research finds
The study also has a second major finding. It is the first study to show that the chances of having a baby after IVF is closely related to the amount of DNA damage a man has in each of his sperm. A little damage is normal (under 15 per cent per sperm), as is seen in the sperm of fertile men. But if the damage reaches clinically important levels (high sperm DNA damage more than 25 per cent per sperm) it will reduce the couples' chances of a family, even with some forms of fertility treatment.

The study also has a second major finding. It is the first study to show that the chances of having a baby after IVF is closely related to the amount of DNA damage a man has in each of his sperm. A little damage is normal (under 15 per cent per sperm), as is seen in the sperm of fertile men. But if the damage reaches clinically important levels (high sperm DNA damage more than 25 per cent per sperm) it will reduce the couples' chances of a family, even with some forms of fertility treatment. These findings are the latest in a series of studies performed by the internationally recognised male fertility research team based at Queen's Centre for Public Health involving over 500 couples.

Source: Science Daily

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