George M Grunert MD, Reproductive Endocrinologist, HFS IVF Program Director

Recurrent Pregnancy Loss

Recurrent Pregnancy Loss (RPL) refers to the loss of two or more pregnancies.Many times the pattern of loss and findings during pregnancy can tell us what happened and why, additional testing may be necessary in some couples to determine the cause.

The majority of first trimester miscarriages are caused by the embryo having extra or missing chromosomes, as described in the section on PGS. Although this most commonly happens at the time of fertilization and embryo growth, in some couples it can be inherited from a parent due to a chromosomal rearrangement (translocation.

Uterine abnormalities, congenital anomalies, fibroids, adhesions, etc., can affect the ability of an embryo to grow. Less commonly, inherited problems with blood clotting (thrombophilias) can affect blood flow to the implanted placenta.

If the miscarriages are genetic, or if no treatable cause is found, the most effective option for women with RPL is IVF with PGS. This allows us to identify and transfer only chromosomally normal (euploid) embryos. Although this does not completely eliminate the chance of miscarriage, it reduces it to less than 10%.

If you have experienced recurrent pregnancy loss, the place to start is with a determination of the cause(s). We can then determine which treatment is best for you. Please contact us or make an appointment for a consultation.

Houston Fertility Specialists Southwest Women’s Health Alliance