George M Grunert MD, Reproductive Endocrinologist, HFS IVF Program Director

Discovery may lead to better egg screening and IVF outcomes

Discovery may lead to better egg screening and IVF outcomes

Experts in in-vitro fertilization (IVF) from UC San Francisco have discovered a pattern of protein secretion during egg maturation that they say has the possibility of leading to a new, non-invasive test to evaluate the fitness of eggs before they are fertilized in the clinic.

In studies of mouse and human eggs, Hakan Cakmak, MD, an assistant professor with the Department of Obstetrics, Gynecology and Reproductive Sciences and the Center for Reproductive Sciences at UCSF and a team of investigators from the same department and center, led by Marco Conti, MD, a professor and the director of the center, have discovered a previously unrecognized pattern of protein secretion by a woman's eggs that normally occurs during their maturation. This secretion plays a vital role in communication between the egg and its supporting cells during the final phase of development, around the time of ovulation, according to the researchers. Their new study was published online on Feb. 8 in the Proceedings of the National Academy of Sciences (PNAS).

Source: Medical Xpress

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